Met ast at ic & Asympt omat ic
Low volume bone disease
Asympt omat ic
Non-met ast at ic
No det ect able disease
Asympt omat ic
Met ast at ic & Sympt omat ic
High volume bone disease
Pain, fat igue, anemia
Ryan et al. NEJM 2013; Beer et al NEJM 2014; Tannock et al NEJM 2004; De Bono et al Lancet
2010; De Bono et al NEJM 2011; Scher et al NEJM 2012; Parker et al NEJM 2013
SG gr
exp
SG gr
control
△
SG
HR
COU-302
35,3m 30,1m
4,8m
0,79
PREVAIL
32,4m 30m
2,4m
0,71
SG gr
exp
SG gr
control
△
SG
HR
TAX-327
18,9m
16,5m
2,4m
0,76
SG gr
exp
SG gr
control
△
SG
HR
TROPIC
15,1m
12,7m
2,4m
0,70
COU-301
15,8m
11,2m
4,6m
0,74
AFFIRM
18,4m
13,6m
4,8m
0,63
SG gr
exp
SG gr
control
△
SG
HR
ALSYMPCA
14m
11,2m
2,8m
0,70
