Uso compasivo alemán
Uso compasivo
europeo
Heidenreich et al. Eur J Cancer 2014; Heidenreich et al. Eur Urol 2013
Probability of Overall Survival (%)
0
10
20
30
40
50
60
70
80
90
100
Time (Months)
0 3 6 9 12 15 18 21 24 27 30 33 36 39 42 45 48
ber at Risk
Z20+PRED 598 469 393 324 210 109 55
30
9
0
Z25+PRED 602 494 416 338 219 120 58
25
11
0
Symbol=Censor
CBZ20+PRED
CBZ25+PRED
Months
Median OS, months (95% CI)
CBZ 20:
13.4 (12.19–14.88
CBZ 25:
14.5 (13.47–15.28)
Estudio PROSELICA
GRADE 3-4
PROSELICA
TROPIC
CBZ 20
N = 595
CBZ 25
N = 580
CBZ 25
N = 371
Neutropenia
14 (2.4)
57 (9.6)
79 (21.3)
Febrile neutropenia
12 (2.1)
55 (9.2)
28 (7.5)
Diarrhea
8 (1.4)
24 (4.0)
23 (6.2)
Fatigue
15 (2.6)
22 (3.7)
18 (4.9)
Toxicidad Cabazitaxel: soporte y dosis
