Antitumoral therapy based on genetically modified T lymphocytes to
express chimeric immunostimulatory molecules
Signal P.
Ectodomain
Endodomain
Transmembrane
Spacer
Immunosuppressive
molec
Coestim molec 1
Coestim molec 2
Spacer
PD-1
CD28
CD137
Recombinant
Retrovirus expressing
Chimeric receptor
Genetically modified
T lymphocyte
LTR
IRES
GFP
LTR
Foxp3 inhibitors
PD1-CD28-CD137
