Genética y epigenética de los SMD: del biomarcador a la terapia - page 62

Transcriptional activation Transcriptional repression
ETO
AML1
---TGTGGT---
CBF
k9 k9 k9
---TGTGGT---
ETO
AML1
CBF
N-
CoR
H
D
A
C H
D
A
C
---TGTGGT---
AML1
CBF ac ac ac
AML1 binding sequence
AML1-ETO
t(8;21)(q22;q22)
panobinostat