Cinco clases de eventos con potencial leucemogénico
en LMA
CEBPA
ETV6
NPM1
RARA
RUNX1
Class II:
Transcription
factors
FLT3
JAK2
KIT
MPL
NF1
PTPN11
N, KRAS
CBL
CBLB
LNK
Class I:
Signaling
CDKN2A/B
TP53, WT1
Class IV:
Tumor suppressors
ASXL1, BCORL1
EZH2, EED,
SUZ12
PHF6,UTX
DNMT3A
IDH1/2
TET2
Class III:
Epigenetic
regulators
SF3B1
SRSF2
U2AF1
ZRSR2
PRPF40B
SF1
SF3A1
U2AF65
Class V:
RNA maturation
Modified from Murati
et al
. BMC Cancer 2012, 12:304
