Genética y epigenética de los SMD: del biomarcador a la terapia - page 64

(Bernt, Epigenomics, 2011; Okada, Cell 2005).
K79 K79 K79 K79
DOT1L
H3K79me2 is found along the gene body
and is linked to an open chromatin state
and transcription elongation.
K4 K4 K4
Transcription aberrantly /
constantly ON
MLL
wt
MLL
Minor groove
DNA binding
AT-hook TRD
Break point
region
AF9
9 der(9) der(11) 11
MLL-AF9
t(9;11)(p22;q23)