Pol II
K4
K4
K4
Transcription ON
MLL
wt
MLL wt
Minor groove
DNA binding
SET
PHD
AT-hook
TRD
H3K4
methyltransferase
activity
Break point
region
(Mohan, Nat Rev Cancer, 2010; Meyer, C. Leukemia, 2009).
H3K4me3
is found on
promoter regions
and is linked to an open chromatin state,
permissive to polII binding and
transcription initiation
.
MLL
wt
9 der(9) der(11) 11
MLL-AF9
t(9;11)(p22;q23)
