Siete clases de eventos con potencial leucemogénico en
SMD
CEBPA, CUX1
ETV6, WT1
NPM1, RUNX1
GATA2
Transcription
factors
FLT3
JAK2
KIT
MPL
NF1
PTPN11
GNB1
NRAS
KRAS
CBL
GNAS
Signaling
TP53, PPM1D
TP53 Pathway
ASXL1, ATRX,
BCOR, BCORL1
EZH2, TET2
DNMT3A
IDH1, IDH2
Epigenetic
regulators
Mofified from Adam S. et al Nature Rev Cancer, 2017, 17, 7, 5-19
STAG2, CTCF,
SMC3, SMC1A,
RAD21
Cohesins
Splicing
SF3B1, SRSF2,
USAF1,ZRSR2,
LUC7L2, U2AF2,
PRPF8, SFI
BRCC3, ATMA,
FANCL, PIGA
Others
